The chemistry of Lake Maggiore has been monitored continuously since 1956. Since 1978 sampling and analyses have been conducted on behalf of the International Commission for the Protection of Italian-Swiss Waters (CIPAIS), which publishes an annual report with results of ongoing research. As part of this activity, in addition to the sampling the water of Lake Maggiore at the point of maximum depth (Ghiffa station), monthly analyses of the main tributaries are conducted, with the aim of calculating the nutrient loads (nitrogen and phosphorous) conveyed to the lake. Apart from research on Lake Maggiore, with monthly samplings, the chemical laboratory of the CNR of Verbania collects data on the other deep subalpine lakes (Garda, Iseo, Como, Lugano and Orta), with an annual sampling at the spring overturn.
Finally, as part of research projects or collaboration with other bodies, research is performed on other Italian lakes to explore and extend knowledge of water chemistry, to define the state of deterioration of the water in relation to anthropogenic pressure and to devise possible intervention strategies. At selected study site also analysis of the main heavy metals are regularly performed.